The Focus on Prevention manual (SAMHSA Publication No. SMA 10‑4120), first published in August 2020, provides communities with a structured framework to design, implement, and evaluate substance use prevention initiatives. Covering the full prevention continuum, it offers practical guidance on conducting community needs assessments, identifying and partnering with stakeholders, developing targeted strategies, marketing prevention efforts, and setting up monitoring and evaluation systems, including a sample timeline of tasks. Intended for non‑profit and faith‑based organizations, this resource equips local coalitions with the tools needed to tailor culturally appropriate and evidence‑informed prevention programs. By emphasizing community collaboration, strategic planning, and measurable outcomes, the manual supports sustainable and effective substance use prevention at the grassroots level.