The SAMHSA resource offers practical guidance for employees, employers, and prevention professionals on navigating work-related stress, burnout, fatigue, and substance misuse challenges. It provides clear strategies for maintaining mental health, supporting coworkers, recognizing signs of distress, and accessing further support, all grounded in behavioral health best practices. For the prevention workforce, this page serves as a tool for integrating mental health and substance use awareness into workplace wellness efforts, enhancing resilience, improving worker well-being, and informing prevention program planning across organizational settings.